Most commands can be keybound, only a few are Axis-only.
It depends a little on what you are flying. In a Spitfire, that Nostromo would be well capable of most used commands in itself (especially when adding shift/alt/ctrl modifiers)
I fly with an X55, but most commands are bound to my throttle, My stick simply has Fire/Brake/Reset TrackIR/Push-to-talk, because I don't want to be multitasking with my stick in a dogfight
Just for fun I bound open/close Canopy to my spacebar and Bailout to CTRL+Numlock 0 to my keyboard, since IRL they'd require to 'take hands off the controls'
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